Following Flemming's discovery of penicillin, it soon became obvious that antibiotics are unstable. This instability appears to be true of all antibiotics. If we compare antibiotics with pyrethrins, however, the problem presumably emerged from the excessively widespread use of a single antibiotic, which continued until a resistant strain of the parasite appeared. Possibly a cocktail of several different antibiotics, used only in life-threatening and otherwise dangerous situations, would be stable.

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