S. variifolium Kuntze.
Saussurea affinis Spreng. ex DC. 585
Family ► Lauraceae.
Habitat ► Canada to Florida. Dried roots of S. albidum are imported into India.
Unani ► Sassafras.
Action ► Root—used earlier for rheumatism, gout, kidney complaints and skin diseases.
Safrole is the main constituent of the volatile oil (80-90%), in addition to condensed tannins, resin, cinnam-ic acid derivatives. Safrole and its metabolite, L-hydroxysafrole are both neuro- and hepatotoxic (carcinogenic in animals). Its internal use is no more advised. Safrole-free extracts are ineffective.
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