Siddha Tamil Karum seeragm

Action ► Seeds—stimulant, carminative, diuretic, lactiferous, em-menagogue (stimulate uterine contractions). Used in puerperal fever. Powdered seeds externally applied to boils. Essential oil— used in common cold, cough and bronchospasm.

The essential oil from seeds contains nigellone and 2-methyl-4-isopropyl-p-quinone. The oil contains carvone (4560%), d-limonene and cymene. Seeds contain fatty acids including palmitic, myristic, stearic, oleic, linoleic and linolenic. Beta-sitosterol is also present in the seeds.

Low concentration of nigellone has been shown to inhibit the release of histamine from mast cells in animals. (Natural Medicines Comprehensive Database, 2007.)

The ethanolic extract of the seeds and the volatile oil from seeds showed antispasmodic activity in experimental animals, possibly due to a calcium antagonistic effect.

The oil exhibited CNS depressant and potent analgesic effects on experimental animals, possibly due to the presence of an opioid principle in the oil.

440 Nilgirianthus ciliatus (Nees) Bremek.

Dosage ► Seed—1-3 g powder (API, Vol. I); 3-5 g powder (CCRAS).

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