Action ► Bark—astringent, styptic (prescribed in bleeding piles, ulcers, haemorrhages, menstrual disorders), anthelmintic. Flowers— astringent, diuretic, emmenagogue (also given for leucorrhoea). A decoction of flowers is given in diarrhoea and haematuria, also to puerperal women. Seeds—clinical use of seeds as an anthelmintic drug is not considered safe in humans.
Leaves—antibacterial. Stem bark— antifungal.
An aqueous extract of flowers has shown hepatoprotective activity against CCl4-induced liver injury in albino rats.
Extracts of flowers have exhibited significant anti-oestrogenic activity in mice. The seed suspension, on oral administration to albino rats (175 and 350 mg/kg body weight), showed 38.46 and 68.75% cases, respectively, where pregnancy was not interrupted but foetus was malformed.
Alcoholic extract of the whole plant produced persistent vasodepression in cats.
The plant contains flavonoids and glucosides—butin, butrin, isobutrin and palastrin. Flowers contain butrin, coreopsin, monospermoside and their derivatives and sulphurein; also chal-cones.
Dosage ► Stem bark—5-10 g powder (API Vol. II); flower—3-6 g powder; seed—3 g powder; gum—0.5-1.5 g (API Vol. IV.)
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