Action ► Bark—febrifuge, antiperi-odic, spasmolytic, antidysenteric, uterine stimulant, hypotensive; used for internal fevers.
Along with other therapeutic applications, The Ayurvedic Pharmacopoeia of India indicates the use of stembark in phosphaturia and recommends it as a blood purifier.
Alternanthera sessilis (Linn.) R. Br. ex DC.
Alstonia sp. is known as Fever Bark. A. constricta is native to Australia; A. scholaris to Australia and Southeast Asia. The bark of both the species contains indole alkaloids. A. constric-ta contains reserpine (a hyptotensive agent). A. scholaris contains echita-mine, which has also demonstrated hypotensive effects. Though A. schol-aris produces fall in the temperature of human patients with fever, there are conflicting reports about the activity of echitamine against Plasmodium berghei.
Dosage ► Stembark—20-30 g for decoction. (API Vol. I.)
major alkaloid, shows monoamine oxidase-inhibitory activity both in vitro and in vivo.
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