Action ► Toxic drug, used only after curing. Fruit—caustic, astringent, anti-inflammatory, antitumour. Used in rheumatoid arthritis and for the treatment of tumours and malignant growths.
A decoction, mixed with milk or butter fat, is prescribed in asthma, neuralgia, sciatica, gout, hemiplegia, epilepsy. Kernel oil—antiseptic; used externally in gout, leucoderma, psoriasis and leprosy. Bark gum—used for nervous debility; in leprous, scrofulous and venereal affections.
The nut shells contain biflavonoids, including tetrahydrobustaflavone, tet-rahydroamentoflavone and anacardu-flavanone; nallaflavone; anacardic acid; aromatic amines and bhilawanol. Bhi-lawanol is a mixture of phenolic compounds, including cis and trans isomers of urushenol (3-pentadecenyl-8' catechol), monohydroxy phenol and semicarpol. These are the major constituents of the shell liquid, isolated from the nuts (about 46% of the weight of extract).
A mixture of closely related pentade-cyl catechols exhibits anticancer activity. Extracts of the fruit was found effective against human epidermoid carcinoma of the naso-pharynx in tissue culture.
Milk extract of the nut showed anti-inflammatory activity against car-rageenin, 5-HT and formaldehyde-induced rat paw oedema in acute anti-inflammatory studies. (About 20% animals developed gangrene of limbs, tail and ears.)
Dosage ► Detoxified fruit—1-2 g in milk confection. (API, Vol. II.)
598 Sempervivum tectorum Linn.
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