Action ► Deobstruent, antihepato-toxic, anticatarrhal, febrifuge. Used in hepatitis, spleen enlargements, chronic skin diseases. Leaf—promotes hair growth. Its extract in oil is applied to scalp before bed time in insomnia. The herb is also used as an ingredient in shampoos.
Key application ► As hepatoprotec-tive. (Indian Herbal Pharmacopoeia; The Ayurvedic Pharmacopoeia of India.)
The herb should be dried at room temperature under shade. Its active principles are lost due to aerial oxidation during sun drying or drying under reduced pressure below 40°C. The herb contains wedelolactone and demethyl-wedelolactone, which showed a dose-dependenteffectagainstCCl4, d-galac-tosamine- or phalloidin-induced cyto-toxicity in primary cultured rat hep-atocytes, and exhibited potent anti-hepatotoxic property. The whole plant shows effect on liver cell regeneration. Immunoactive property has been observed against surface antigen of hepatitis B-virus. The plant is also reported to be effective in the treatment of peptic ulcer, inflammatory diseases, including rheumatoid arthritis, diseases of the gallbladder and skin infections.
Aqueous extract of leaves exhibits myocardial depressant and hypoten-sive activity (unrelated to cholinergic and histaminergic effects).
The roots are very rich in thio-phene acetylenes. Thiophene derivatives show activity against nematodes.
Dosage ► Whole plant—3-6 ml fresh juice; 13-36 g for decoction. (API Vol. II.)
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