Solanum nigrum Linn. 613
Action ► Fruit—recommended in liver complaints and for amenorrhoea. The fruit is reported to stimulate the intrahepatic metabolism of cholesterol, produces a marked drop in blood cholesterol level. Aqueous extract of fruit is reported to inhibit choline esterase activity of human plasma. Root—antiasthmatic. Leaves—toxic; used mostly externally for the treatment of burns, cold sores and abscesses. Seeds—anticholesterolemic.
Steroidal saponins, melongosides were isolated from seeds; tigogenin, diosgenin were also obtained. Querce-tin, 3-O-rhamnoside and kaempferol-3-O-rutinoside have been isolated from the leaves. The ethanol extract (80%) showed anti-inflammatory activity in paw oedema and cotton pellet method in rats. Crude extract of fruits showed diuresis and dose-dependent hypotensive response in normotensive rats. Ether-soluble methanolic extract exhibited strong inhibitory activity on lipoxygenase, involved in atherosclerotic processes and platelet aggregation in rats.
Solanum melongena Linn. var. incanum Kuntze, synonym S. coagulans Forsk is known as Bana-bhantaa (also a synonym of Solanum ferox) and is used as Brihati in Kerala. Air-dried fruits and leaves from coimbatore contain 1.05 and 0.97% of alkaloids respectively. The fruits contain solaso-dine, campesterol and beta-sitosterol. Solamargine, solasodine, ursolic acid and its derivatives exhibited significant cytotoxic effects against human P2C/PRF/5 cells in vitro.
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